Globin Gene Expression in Sickle Cell Genotype-Specific iPSC

The major goal of this project is to use an iPSC-based approach to recapitulate in vitro erythroid ontogeny as the basis to study globin switching in sickle cell disease-specific iPSC.

iPSC Modeling of Mulisystemic, Hereditary Transthyretin Amyloidosis

This work involves the successful modeling of familial amyloidosis in vitro with the use of iPSC technology, demonstrating that it is possible to model a long-term, complex, multisystem disease in a relatively short time, using lineage-specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells.

iPSCs for Drug Discovery: the Clinical Trial in a Test Tube


Progressing towards the first-in-human trials of iPSC-derived blood products



Understanding human hematopoietic development

The goal of this project is to study how blood cells form throughout human development.

This video demonstrates the formation of round blood cells which are birthed from hemogenic endothelium created from iPSCS.

Pathophysiology of Sickle Cell Disease

Diagram courtesy of Martin Steinberg.

Red Blood Cell Animation