Anthony’s paper characterizing lung megakaryocytes is out in Blood Advances!

Click here to read his paper! 

CReM team, led by Dr. Murphy, develops rapid in-house COVID19 test to support BMC

Click here for info on the CReM’s testing operation (BU’s The Brink)

Click here to read about the clinical impact of the CReM’s efforts (HealthCity)

Click here for more on how academic labs, including the CReM, rose up to the COVID-19 testing challenge (WBUR)

Rich’s paper on hepatic proteostasis in amyloid disease is accepted to Stem Cell Reports!

Visit the article in Stem Cell Reports

View the paper’s video abstract

iPSC-based modeling of resiliency in centenarians

Screen Shot 2019-11-23 at 10.17.42 PM

Globin Gene Expression in Sickle Cell Genotype-Specific iPSC

The major goal of this project is to use an iPSC-based approach to recapitulate in vitro erythroid ontogeny as the basis to study globin switching in sickle cell disease-specific iPSC.

iPSC Modeling of Mulisystemic, Hereditary Transthyretin Amyloidosis

This work involves the successful modeling of familial amyloidosis in vitro with the use of iPSC technology, demonstrating that it is possible to model a long-term, complex, multisystem disease in a relatively short time, using lineage-specified cells (hepatic, cardiac and neuronal) derived from patient-specific stem cells.

iPSCs for Drug Discovery: the Clinical Trial in a Test Tube

1


Progressing towards the first-in-human trials of iPSC-derived blood products

4

 

Understanding human hematopoietic development

The goal of this project is to study how blood cells form throughout human development.

This video demonstrates the formation of round blood cells which are birthed from hemogenic endothelium created from iPSCS.

Pathophysiology of Sickle Cell Disease

Diagram courtesy of Martin Steinberg.