Murphy Lab Publishes iPSC-based model of amyloid disease in Stem Cell Reports

 induced Pluripotent Stem Cells or iPSCs are a form of stem cells that come from skin or blood cells that are changed into cells that have the ability to become any type of tissue in the body. ATTR is a lethal genetic disease in which mutant protein secreted from the liver damages the heart and the brain, highlighting the need for a flexible model system that would allow physicians and scientists to study the disease

According to researchers using this technology, cell lines can be created that are genetically identical to the patient from whom they are derived, allowing for the development of personalized treatments for diseases.

In this study, the researchers used the iPSCs to make liver cells that produce mutant protein as well as cells of the heart and brain, the target tissues of the disease.  Upon addition of the mutant protein, the heart and brain cells were damaged, thereby recreating essential aspects of the disease. Furthermore, drugs that are being tested in clinical trials prevented this damage in the cells suggesting that this system can be used to test new drugs for treatment of the disease.

Read the paper here:  http://www.cell.com/stem-cell-reports/abstract/S2213-6711(13)00097-0

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Richard presents his work at the International Symposium on Amyloidosis in Kumamoto, Japan

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Murphy lab publishes an improved protocol for generating HSPCs from iPSCs in Stem Cells

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Richard is awarded a Junior Researcher Travel Award for the XVIth International Symposium on Amyloidosis in Kumamoto, Japan

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Kim is awarded an ASH Abstract Achievement Award for her work submitted to the 2017 ASH Meeting

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Congratulations to Spoorthi who begins her medical school training at BU’s 2017 white coat ceremony!

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Boston Magazine features the CReM and the Murphy lab

Blood tube at the microbiology laboratory

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Murphy Lab and the CReM Featured on CBS Boston with Dr. Mallika Marshall: Brewing Blood

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Richard’s poster wins first prize at the 2017 BU-CTSI Annual Translational Research Symposium!

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Drs. Murphy, Mostoslavsky and Steinberg create the world’s largest sickle cell disease-specific iPSC library

Gustavo Marty George

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Dr. Murphy awarded Scholar Award from the National Blood Foundation

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