Murphy Lab Publishes iPSC-based model of amyloid disease in Stem Cell Reports

 induced Pluripotent Stem Cells or iPSCs are a form of stem cells that come from skin or blood cells that are changed into cells that have the ability to become any type of tissue in the body. ATTR is a lethal genetic disease in which mutant protein secreted from the liver damages the heart and the brain, highlighting the need for a flexible model system that would allow physicians and scientists to study the disease

According to researchers using this technology, cell lines can be created that are genetically identical to the patient from whom they are derived, allowing for the development of personalized treatments for diseases.

In this study, the researchers used the iPSCs to make liver cells that produce mutant protein as well as cells of the heart and brain, the target tissues of the disease.  Upon addition of the mutant protein, the heart and brain cells were damaged, thereby recreating essential aspects of the disease. Furthermore, drugs that are being tested in clinical trials prevented this damage in the cells suggesting that this system can be used to test new drugs for treatment of the disease.

Read the paper here:  http://www.cell.com/stem-cell-reports/abstract/S2213-6711(13)00097-0

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Student Profile: Sarah Rozelle

Sarah Rozelle, a graduate student in the Murphy lab, is profiled on the Boston University School of Medicine webpage…click on the link to read more…

Shirley Nah wins Evan’s Day research award

Shirley Nah, a Master’s student in the Murphy Lab, was presented a prestigious research award by David Coleman for her work involving the induced pluripotent stem cell modeling of neurodegenerative disease.

Shirley Nah presenting her data at BU Evan’s Day

Sarah Rozelle presents her work to past and present NIH directors

Sarah Rozelle Presents at the 18th Annual Switching Meeting


Sarah Rozelle, a 3rd year graduate student in the Murphy Lab was selected to give an oral presentation of her work at the 18th annual Globin Switching meeting held at the Asilomar Conference Center, Monterey, CA.

Murphy Lab Receives New NIH Grant

Boston University researchers, led by Drs. George J. Murphy and Martin Steinberg, have developed a way to test treatments for sickle cell disease – a genetic disorder of the blood – by working with pluripotent stem cells grown from a small amount of the patient’s own blood.  Click on the picture to link to the full article.

Amy Leung wins Research Award

Amy Leung, Ph.D, a postdoctoral fellow in the Murphy Lab was awarded a prestigious research award following the presentation of her work at the International Symposium on Amyloidosis in Groningen, The Netherlands, 6-10 May 2012.

CReM Directors Profiled in Bostonia

More Than Just Skin Deep:  Read more about the CReM Directors by clicking on this link…

Murphy Lab Awarded Amyloidosis Foundation Grant

“Induced Pluripotent Stem Cell Modeling of Human Hereditary Amyloidosis”
This project will generate a new form of stem cells that start out as skin or blood cells but are then reprogrammed into cells that have the ability to become any type of tissue in the body. These stem cells will be utilized to study a genetic disease through the directed differentiation of these cells in vitro in order to recapitulate the outcome of the disease. Possible benefits of this research are new ways to study treatments for genetic diseases such as familial amyloidosis.

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Dr. Murphy chosen as an American Society of Hematology Scholar

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